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Interaction of Mycophenolic Acid and Pantoprazole


Interaction of Mycophenolic Acid and Pantoprazole

Author: Olesja Rissling

language: en

Publisher: Springer

Release Date: 2017-11-01

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Olesja Rissling analyzes the potential interaction of mycophenolic acid (MPA) and pantoprazole. MPA is used as an immunosuppressive drug to prevent acute organ rejections after organ transplantation. Pantoprazole, known to interact with the bioavailability of drugs, is used to prevent upper gastrointestinal disorders. The author performed a clinical pharmacokinetic study in renal transplant patients to evaluate a potential interaction of MPA and pantoprazole. The bioavailability and the maximum concentration of MPA were determined with or without pantoprazole intake. An influence on the immunosuppressive effect was evaluated by measuring the target enzyme activity. Overall, no significant change in the bioavailability or the maximum concentration was found. Similar results were obtained for the target enzyme activity after pantoprazole intake with MPA. The results suggest that the interaction of pantoprazole with MPA does not compromise the immunosuppressive effect to a clinically meaningful extent.

Drug-Induced Liver Injury


Drug-Induced Liver Injury

Author:

language: en

Publisher: Academic Press

Release Date: 2019-07-13

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Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

The PDR Pocket Guide to Prescription Drugs, 8th Edition (EAN)


The PDR Pocket Guide to Prescription Drugs, 8th Edition (EAN)

Author: Thompson PDR

language: en

Publisher: Simon and Schuster

Release Date: 2007-12-26

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This completely revised edition of the renowned guide doctors depend on features all-new, important sections about side effects, drug and food interactions, and much more. Includes A-Z listings of more than 1,000 brand-name and generic drugs. Original.